Adrenalin: Fear the Rush depicts a 2007 where the geopolitical and biological fabric of the world has unraveled. Following the collapse of the Russian Federation, a catastrophic viral plague—initially a leaked biochemical weapon—sweeps across Eastern Europe and eventually reaches the United States. The film focuses on a quarantined Boston, reimagined as a damp, decaying fortress where immigrants and refugees are confined under strict military supervision. Earth is portrayed as a collection of walled city-states struggling to contain both the infection and the resulting social anarchy.

The societal dynamics are defined by a rigid class divide between the "healthy" and the "sick," enforced by a police state. The film suggests an alternate timeline where the post-Cold War era led not to global integration but to a violent fragmentation along ethnic and health-status lines. A notable divergence from reality is the film's depiction of the Russian Federation's total collapse into anarchy shortly after the fall of Communism, leading to a world where international travel is governed by high-security black-market passports and lethal containment protocols.

Technologically and socially, the film’s vision of 2007 serves as a grim precursor to real-world anxieties regarding global pandemics and border security. While the specific "superhuman" mutation caused by the virus remains firmly in the realm of sci-fi horror, the depiction of urban militarization and the use of large-scale physical barriers to manage refugee populations mirrors later 21st-century political shifts. The film's prediction of a singular, world-altering viral event causing the suspension of civil liberties and the creation of permanent "temporary" quarantine zones reflects a cynical but accurate foresight into how modern states react to biological threats.