Set in a bleak 2025, Endgame depicts an Earth transformed into a radioactive necropolis following a global nuclear conflict. Society has regressed into a brutal hierarchy where the elite reside in a high-tech "City" while the masses participate in or observe Endgame, a televised gladiatorial hunt where warriors kill for sport and ratings.

The societal dynamics revolve around the exploitation of mutants—humans evolved with telepathic abilities—who are hunted by both the state and scavengers. The environment is characterized by extreme urban decay and poisoned landscapes, suggesting an Earth that has become biologically hostile to traditional human life. The political structure is a loose totalitarianism maintained through media-driven violence and military suppression of the mutant subclass.

While the film's 2025 date has arrived without a nuclear apocalypse, it offers a striking prediction of hyper-violent reality media and the gamification of survival, echoing themes later found in The Running Man. The depiction of telepathic evolution acts as a metaphor for social alienation rather than a literal scientific forecast. Comparison to contemporary 2026 shows that while we lack the mutant uprisings depicted, the film's vision of widening class divides and crumbling infrastructure in neglected urban zones remains a resonant, if hyperbolic, social critique. Fewer than three analysis-quality academic sources exist for this specific cult title, so predictions are primarily inferred from its genre-standard tropes and worldbuilding cues.