Set in a devastated 2019, Mutant War depicts an Earth that has transitioned from a victim of alien invasion to a post-apocalyptic wasteland defined by ecological collapse and biological horror. Following the events of its predecessor, Battle for the Lost Planet, the world is now a scarred landscape where the "Neutron 90" bomb—originally deployed to melt alien invaders—has left behind a legacy of lethal radiation and warped lifeforms. The film establishes Earth as a broken "comfort station" for extraterrestrial beings, where the remnants of humanity are hunted or exploited by both mutants and opportunistic human warlords.

The societal dynamic is one of absolute lawlessness and scavenging. Civilized structures have been replaced by a primitive, violent hierarchy centered around survival and reproduction. A key driver of the plot is the intergalactic slave trade, where human women are kidnapped for breeding purposes by villains like Reinhardt Rex. This reflects a dark interpretation of Earth's role in a larger galactic ecosystem: rather than a sovereign planet, it is treated as a resource-depleted colony or a lawless frontier territory where human biology itself has become a commodity.

Technologically and environmentally, the film presents a curious duality. While the narrative explicitly cites the greenhouse effect and nuclear fallout as the primary architects of Earth's ruin, the actual depiction of 2019 features 1980s-era firearms and vehicles, implying a total halt in terrestrial innovation following the invasion. In contrast to real-world 2019, which saw the rise of digital globalization and high-tech surveillance, the film's vision is one of technological regression. However, its prediction of environmental degradation leading to resource wars and the breakdown of centralized government mirrors modern anxieties regarding climate-driven instability, albeit through the sensationalist lens of low-budget sci-fi. Because there are fewer than three analysis-quality sources focused on its prophetic value, these comparisons are inferred from its narrative emphasis on ecological catastrophe and societal collapse.