Set in the year 2021, The Sisterhood depicts an Earth ravaged by a global nuclear holocaust that occurred decades prior. The remnants of humanity inhabit a scorched landscape where formal civilization has vanished, replaced by a regressive, feudal social structure. The environment is characterized by extreme desertification and resource scarcity, where survival depends on scavenging and physical dominance.

The societal dynamic is defined by a rigid gender-based conflict. A brutal army of men seeks to enslave or eliminate the few remaining pockets of resistance, most notably a group of women known as 'The Sisterhood.' These women represent a psionic evolution of the human species, possessing telepathic and telekinetic abilities as a byproduct of radiation-induced mutation. This creates a divergence from our timeline where biological evolution accelerated following a 1980s-era nuclear anxiety event.

In terms of predictions, the film's vision of 2021 failed to materialize the Mad Max-style total collapse of infrastructure. While the film correctly anticipated increasing environmental volatility and water scarcity as modern concerns, it missed the digital revolution entirely, opting for a 'low-tech' future where horses and melee weapons are primary tools. The prediction of telepathy remains purely speculative, though the film serves as a cultural artifact reflecting late-Cold War fears that the early 21st century would be defined by the aftermath of atomic war. Due to the limited critical analysis available for this specific B-movie, certain interpretations regarding its worldbuilding are inferred from its exploitation-genre tropes.